SCHEMBL7462893

SCHEMBL7462893

C=CC(=O)c1ccc(-n2ccnc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.64
BAZ2B Q9UIF8 1/20 0.64
ADH5 P11766 5/20 0.60
MAOB P27338 3/20 0.59
HTT P42858 1/20 0.59
HTR2A P28223 1/20 0.57
HTR2C P28335 1/20 0.57
HTR2B P41595 1/20 0.57
ENPP2 Q13822 1/20 0.54
MKNK1 Q9BUB5 1/20 0.54
MKNK2 Q9HBH9 1/20 0.54
MAPT P10636 3/20 0.50
LMNA P02545 2/20 0.50
NOTUM Q6P988 1/20 0.50
PDE4A P27815 1/20 0.49
PDE4B Q07343 1/20 0.49
PDE4C Q08493 1/20 0.49
PDE4D Q08499 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10574724 0.81 CYP3A4 (0.74) CYP3A4BAZ2BADH5MAOBHTT
SCHEMBL3301878 0.80 ADH5 (0.60) CYP3A4BAZ2BADH5MAOBHTT
SCHEMBL3301874 0.80 ADH5 (0.60) CYP3A4BAZ2BADH5MAOBHTT
SCHEMBL3301872 0.80 ADH5 (0.60) CYP3A4BAZ2BADH5MAOBHTT
SCHEMBL62049 0.80 ADH5 (0.90) CYP3A4BAZ2BADH5HTTHTR2A
Acrylic Acid SCHEMBL28324903 0.79 CYP3A4 (0.70) CYP3A4BAZ2BADH5HTTHTR2A
SCHEMBL10363643 0.78 CYP3A4 (0.53) CYP3A4BAZ2BADH5HTTHTR2A
SCHEMBL4661827 0.78 CYP3A4 (0.53) CYP3A4BAZ2BADH5HTTHTR2A
Hydrochloric Acid SCHEMBL6152702 0.78 ADH5 (0.87) CYP3A4BAZ2BADH5HTTHTR2A
SCHEMBL3097162 0.78 CYP3A4 (0.70) CYP3A4BAZ2BADH5MAOBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5021436-A Antiulcer, anticoagulant, antiischaemic agent BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) 1991-06-04 US disclosed
EP-0233228-A1 PHARMACEUTICALLY ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1987-08-26 EP disclosed
WO-1987000836-A1 PHARMACEUTICALLY ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDROPYRIDINES BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) 1987-02-12 WO disclosed