Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2234114 | 0.84 | SLC1A2 (0.54) | HDAC1HDAC3HDAC7HDAC2HDAC8 | |
| SCHEMBL7471469 | 0.82 | HDAC1 (0.58) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL7417166 | 0.79 | MEN1 (0.64) | HDAC1HDAC3HDAC7HDAC2HDAC8 | |
| SCHEMBL12515063 | 0.78 | HDAC3 (0.47) | HDAC1HDAC3HDAC7HDAC2HDAC8 | |
| SCHEMBL13175274 | 0.74 | HDAC1 (0.66) | HDAC1HDAC3HDAC7HDAC2HDAC8 | |
| SCHEMBL8090912 | 0.74 | HDAC1 (0.66) | HDAC1HDAC3HDAC7HDAC2HDAC8 | |
| SCHEMBL27529872 | 0.74 | SLC1A2 (0.63) | HDAC1HDAC3HDAC7HDAC2HDAC8 | |
| SCHEMBL12262967 | 0.74 | SLC1A2 (0.63) | HDAC1HDAC3HDAC7HDAC2HDAC8 | |
| SCHEMBL2840189 | 0.72 | LMNA (0.59) | HDAC1HDAC3HDAC7HDAC2HDAC8 | |
| SCHEMBL7417076 | 0.71 | NPC1 (0.51) | HDAC1HDAC3HDAC7HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |