Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.49 |
| ▸ | AKT1 | P31749 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | NEK4 | P51957 | 3/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.49 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415740 | 0.86 | EPHX2 (0.54) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL22995641 | 0.85 | MEN1 (0.61) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL5027698 | 0.85 | MEN1 (0.61) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL3717471 | 0.85 | MEN1 (0.61) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL30075239 | 0.84 | MEN1 (0.55) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL30898781 | 0.84 | MEN1 (0.55) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL14327771 | 0.83 | MEN1 (0.59) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL27553133 | 0.82 | MEN1 (0.66) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL2777735 | 0.80 | ROCK2 (0.70) | MEN1KMT2ALMNAKDM4EGAA | |
| SCHEMBL9293287 | 0.80 | ROCK2 (0.70) | MEN1KMT2ALMNAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| CN-1265647-A | Acyclic metalloprotease inhibitors | PROCTER & GAMBLE (US) | 2000-09-06 | — | — | CN | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |