Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | CCR1 | P32246 | 3/20 | 0.57 |
| ▸ | CCR5 | P51681 | 3/20 | 0.57 |
| ▸ | CCR8 | P51685 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ALPL | P05186 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | ALPI | P09923 | 1/20 | 0.57 |
| ▸ | ALPG | P10696 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22231735 | 0.81 | KDM4E (0.59) | KDM4ETP53SMN1; SMN2CCR1CCR5 | |
| SCHEMBL776048 | 0.79 | KDM4E (0.67) | KDM4ETP53SMN1; SMN2CCR1CCR5 | |
| SCHEMBL6535045 | 0.79 | KDM4E (0.67) | KDM4ETP53SMN1; SMN2CCR1CCR5 | |
| SCHEMBL12824407 | 0.77 | KDM4E (0.71) | KDM4ETP53SMN1; SMN2CCR1CCR5 | |
| SCHEMBL22232393 | 0.77 | ADRB2 (0.41) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| Dipyridyl SCHEMBL28562697 | 0.77 | KDM4E (0.74) | KDM4ETP53SMN1; SMN2CCR1CCR5 | |
| SCHEMBL7467894 | 0.76 | ABL1 (0.48) | LMNAHTTHSP90AA1NPC1RAB9A | |
| SCHEMBL29462395 | 0.76 | HSP90AA1 (0.62) | KDM4ETP53SMN1; SMN2CCR1CCR5 | |
| SCHEMBL3978651 | 0.76 | KDM4E (0.52) | KDM4ETP53SMN1; SMN2CCR1CCR5 | |
| SCHEMBL460135 | 0.76 | HSP90AA1 (0.62) | KDM4ETP53SMN1; SMN2CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |