Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | PNP | P00491 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27336080 | 0.78 | CSNK2A1 (0.44) | PIM1CSNK2A1ADORA3ADORA2AADORA1 | |
| SCHEMBL7469470 | 0.77 | DPYD (0.40) | ALDH1A1MAPK1 | |
| SCHEMBL7467007 | 0.77 | KDM4E (0.38) | CSNK2BCSNK2A1ADORA3ADORA2AADORA1 | |
| SCHEMBL7468346 | 0.74 | SMN1; SMN2 (0.43) | ALDH1A1GLA | |
| SCHEMBL19242505 | 0.68 | PARP1 (0.41) | CSNK2A1PNPADORA3ALDH1A1 | |
| SCHEMBL22487726 | 0.67 | SLC2A1 (0.58) | PNPADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL7443209 | 0.67 | KDM4E (0.40) | GSK3BADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL6979552 | 0.67 | PPARG (0.46) | GSK3BCDC7PIM1CSNK2BCSNK2A1 | |
| SCHEMBL16475170 | 0.65 | PDPK1 (0.50) | CSNK2BCSNK2A1PNPALDH1A1MAPK1 | |
| SCHEMBL22487730 | 0.63 | ACHE (0.37) | GSK3BADORA2AADORA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492384-B1 | Imidazo (4,5-C) pyridine-4-one derivatives with factor XA inhibiting effect | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1117664-A1 | IMIDAZO[4,5-C-]-PYRIDINE-4-ONE DERIVATIVES WITH FACTOR XA INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000020416-A1 | IMIDAZO[4,5-C-]-PYRIDINE-4-ONE DERIVATIVES WITH FACTOR XA INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2000-04-13 | — | — | WO | disclosed |