Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 12/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454194 | 0.81 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7444904 | 0.74 | GABRG2 (0.56) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL4918827 | 0.70 | GABRG2 (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL4401833 | 0.70 | NPSR1 (0.68) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7452104 | 0.70 | NPSR1 (0.68) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7457238 | 0.69 | NPSR1 (0.56) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7369406 | 0.69 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL4931496 | 0.69 | NPSR1 (0.62) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7459195 | 0.68 | NPSR1 (0.75) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7458560 | 0.68 | NPSR1 (0.64) | GABRG2GABRB3GABRA5GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937072-B1 | THIENYLCYCLOHEXANONE DERIVATIVES AS LIGANDS OF THE GABA A alpha5 RECEPTOR SUBTYPE | MERCK SHARP & DOHME (GB) | 2002-01-09 | — | — | EP | claimed |