Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 14/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 14/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 14/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 11/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4401833 | 0.77 | NPSR1 (0.68) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7452104 | 0.77 | NPSR1 (0.68) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL4918827 | 0.77 | GABRG2 (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7457238 | 0.76 | NPSR1 (0.56) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL4931496 | 0.75 | NPSR1 (0.62) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7459195 | 0.74 | NPSR1 (0.75) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7463304 | 0.74 | GABRG2 (0.50) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7458560 | 0.74 | NPSR1 (0.64) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7416729 | 0.74 | NPSR1 (0.64) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL6799646 | 0.73 | KDM4E (0.60) | GABRG2GABRB3GABRA5GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937072-B1 | THIENYLCYCLOHEXANONE DERIVATIVES AS LIGANDS OF THE GABA A alpha5 RECEPTOR SUBTYPE | MERCK SHARP & DOHME (GB) | 2002-01-09 | — | — | EP | disclosed |
| US-6262103-B1 | ALZHEIMER'S DISEASE. | MERCK SHARP & DOHME LIMITED (GB) | 2001-07-17 | — | — | US | disclosed |
| US-6143773-A | Substituted thienobenzisoxazole derivatives for enhancing cognition | MERCK SHARP & DOHME LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |
| EP-0937072-A1 | THIENYLCYCLOHEXANONE DERIVATIVES AS LIGANDS OF THE GABA A? $g(a)5 RECEPTOR SUBTYPE | MERCK SHARP & DOHME LTD. (GB) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998018792-A1 | THIENYLCYCLOHEXANONE DERIVATIVES AS LIGANDS OF THE GABAA α5 RECEPTOR SUBTYPE | MERCK SHARP & DOHME LIMITED (GB) | 1998-05-07 | — | — | WO | disclosed |