Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | GRK2 | P25098 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MIF | P14174 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7506811 | 0.87 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2MIFHDAC6 | |
| SCHEMBL7470351 | 0.86 | MIF (0.60) | NPC1RAB9ASMN1; SMN2MIFHDAC6 | |
| SCHEMBL7505962 | 0.86 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2MIFHDAC6 | |
| SCHEMBL7505956 | 0.86 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2MIFHDAC6 | |
| SCHEMBL13298912 | 0.85 | MIF (0.59) | NPC1RAB9ASMN1; SMN2MIFHDAC6 | |
| SCHEMBL7507447 | 0.85 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2MIFHDAC6 | |
| SCHEMBL13438275 | 0.84 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2MIFHDAC6 | |
| SCHEMBL3327267 | 0.83 | MIF (0.57) | NPC1RAB9ASMN1; SMN2MIFHDAC6 | |
| SCHEMBL7464403 | 0.83 | MIF (0.53) | NPC1RAB9ASMN1; SMN2MIFHDAC6 | |
| SCHEMBL3325154 | 0.81 | MIF (0.55) | NPC1RAB9ASMN1; SMN2MIFHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054874-B1 | SUBSTITUTED AMINOPHENYL ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | UPJOHN CO (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1054874-A1 | SUBSTITUTED AMINOPHENYL ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | PHARMACIA & UPJOHN COMPANY (US) | 2000-11-29 | — | — | EP | disclosed |
| US-6069141-A | BACTERICIDES | PHARMACIA & UPJOHN COMPANY (US) | 2000-05-30 | — | — | US | disclosed |
| WO-1999041244-A1 | SUBSTITUTED AMINOPHENYL ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | PHARMACIA & UPJOHN COMPANY (US) | 1999-08-19 | — | — | WO | disclosed |