Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.55 |
| ▸ | MMP1 | P03956 | 2/20 | 0.51 |
| ▸ | MMP9 | P14780 | 2/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 10/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL7459041 | 0.93 | HRH3 (0.52) | HRH3MMP1MMP9MMP13ADAM17 | |
| Hydroxyamine SCHEMBL7463488 | 0.89 | S1PR5 (0.52) | HRH3MMP1MMP9MMP13ADAM17 | |
| SCHEMBL27555705 | 0.87 | S1PR5 (0.54) | HRH3MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7619211 | 0.87 | S1PR5 (0.53) | HRH3MMP1MMP9MMP13ADAM17 | |
| Hydroxyamine SCHEMBL7661687 | 0.87 | MMP1 (0.51) | HRH3MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7555893 | 0.86 | S1PR5 (0.53) | HRH3MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7570327 | 0.85 | MMP1 (0.53) | HRH3MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7512979 | 0.83 | MMP1 (0.57) | HRH3MMP1MMP9MMP13ADAM17 | |
| Hydroxyamine SCHEMBL7462750 | 0.82 | KCNH2 (0.46) | HRH3MMP1MMP9MMP13ADAM17 | |
| Hydroxyamine SCHEMBL7577224 | 0.79 | S1PR5 (0.45) | MMP1S1PR5S1PR1KCNH2S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054858-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999042436-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-08-26 | — | — | WO | disclosed |