Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 3/20 | 0.51 |
| ▸ | BRD2 | P25440 | 2/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9842833 | 0.92 | ALDH1A1 (0.67) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9842911 | 0.91 | MEN1 (0.62) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9842882 | 0.90 | MEN1 (0.60) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9842568 | 0.89 | PDE4A (0.59) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9842775 | 0.85 | SMN1; SMN2 (0.47) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9842711 | 0.83 | MEN1 (0.49) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9842637 | 0.82 | MAPK1 (0.52) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9615238 | 0.82 | SMN1; SMN2 (0.44) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9842532 | 0.82 | CYP3A4 (0.62) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL1495090 | 0.80 | PDE4A (0.76) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771813-B1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AG (DE) | 2002-01-16 | — | — | EP | disclosed |
| US-5728686-A | TREATMENT OF MUSCULAR DYSTROPHY | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-17 | — | — | US | disclosed |
| EP-0771813-A1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-07 | — | — | EP | disclosed |
| EP-0430025-A2 | Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1991-06-05 | — | — | EP | disclosed |