SCHEMBL7464315

SCHEMBL7464315

CCc1cc(CN2C(=O)CSC2=O)ccc1-c1cc2c(cc1C)C(C)(C)CCC2(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 3/20 0.45
GSK3B P49841 3/20 0.45
POLB P06746 1/20 0.44
ALDH1A1 P00352 3/20 0.43
RXRA P19793 7/20 0.41
RXRG P48443 2/20 0.41
RXRB P28702 1/20 0.41
HDAC1 Q13547 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
RARB P10826 1/20 0.38
RARG P13631 1/20 0.38
PPARG P37231 1/20 0.37
GFER P55789 1/20 0.37
PIM1 P11309 1/20 0.37
KCNN4 O15554 1/20 0.34
MET P08581 1/20 0.34
FGFR1 P11362 1/20 0.34
FGFR2 P21802 1/20 0.34
FGFR3 P22607 1/20 0.34
AXL P30530 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7460353 0.92 GSK3A (0.48) GSK3AGSK3BPOLBALDH1A1RXRA
SCHEMBL7463442 0.89 ALDH1A1 (0.46) GSK3AGSK3BPOLBALDH1A1RXRA
SCHEMBL7461714 0.88 GSK3A (0.44) GSK3AGSK3BPOLBALDH1A1RXRA
SCHEMBL7464561 0.88 GSK3A (0.47) GSK3AGSK3BPOLBALDH1A1RXRA
SCHEMBL7457132 0.87 GSK3A (0.41) GSK3AGSK3BPOLBALDH1A1RXRA
SCHEMBL7466516 0.87 GSK3A (0.43) GSK3AGSK3BPOLBALDH1A1RXRA
SCHEMBL7468575 0.87 KMT2A (0.46) GSK3AGSK3BPOLBALDH1A1RXRA
SCHEMBL5485145 0.86 RXRA (0.46) GSK3AGSK3BPOLBALDH1A1RXRA
SCHEMBL7466491 0.86 POLB (0.43) GSK3AGSK3BPOLBALDH1A1RXRA
SCHEMBL7463053 0.86 POLB (0.43) GSK3AGSK3BPOLBALDH1A1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214305-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION Maxia Pharmaceuticals, Inc. (US) 2002-06-19 EP claimed
WO-2001016123-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION MAXIA PHARMACEUTICALS, INC. (US) 2001-03-08 WO claimed
EP-1214305-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION Maxia Pharmaceuticals, Inc. (US) 2002-06-19 EP disclosed
WO-2001016123-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION MAXIA PHARMACEUTICALS, INC. (US) 2001-03-08 WO disclosed