Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27456003 | 0.88 | HTR2A (0.50) | HTR2AHTR2BHTR2CTAAR1SIGMAR1 | |
| SCHEMBL8403636 | 0.81 | HTR2A (0.53) | HTR2AHTR2BHTR2CTAAR1SIGMAR1 | |
| SCHEMBL7471740 | 0.80 | TAAR1 (0.40) | TAAR1IDO1 | |
| SCHEMBL28143319 | 0.80 | TAAR1 (0.59) | HTR2AHTR2BHTR2CTAAR1SIGMAR1 | |
| SCHEMBL28260251 | 0.80 | TAAR1 (0.59) | HTR2AHTR2BHTR2CTAAR1SIGMAR1 | |
| SCHEMBL2094737 | 0.80 | TAAR1 (0.59) | HTR2AHTR2BHTR2CTAAR1SIGMAR1 | |
| SCHEMBL28261580 | 0.80 | TAAR1 (0.59) | HTR2AHTR2BHTR2CTAAR1SIGMAR1 | |
| SCHEMBL7929109 | 0.78 | TAAR1 (0.61) | HTR2AHTR2BHTR2CTAAR1SIGMAR1 | |
| SCHEMBL7470784 | 0.77 | CHRM2 (0.42) | TAAR1EPHX1 | |
| SCHEMBL256694 | 0.76 | TAAR1 (0.62) | HTR2AHTR2BHTR2CTAAR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244617-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047875-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-07-05 | — | — | WO | disclosed |