Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22540303 | 0.84 | TDP1 (0.61) | KMT2AGBA1ALDH1A1MEN1MAPT | |
| SCHEMBL7464373 | 0.80 | MAPT (0.38) | KMT2AALDH1A1MEN1MAPTL3MBTL1 | |
| SCHEMBL1960773 | 0.78 | — | — | |
| SCHEMBL1593852 | 0.78 | PTGES (0.47) | KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL5123336 | 0.78 | PTGES (0.47) | KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL674276 | 0.76 | GBA1 (0.71) | MGLLGBA1ALDH1A1PRMT3CARM1 | |
| SCHEMBL2027845 | 0.76 | GBA1 (0.71) | MGLLGBA1ALDH1A1PRMT3CARM1 | |
| SCHEMBL1593854 | 0.75 | TSHR (0.66) | KMT2AALDH1A1MEN1 | |
| SCHEMBL5392371 | 0.75 | TSHR (0.66) | KMT2AALDH1A1MEN1 | |
| Ammonia Solution, Strong SCHEMBL1432566 | 0.74 | GBA1 (0.68) | MGLLGBA1ALDH1A1PRMT3CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194421-A4 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1194421-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001002379-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |