SCHEMBL7464441

SCHEMBL7464441

Cc1sccc1-c1cc(N)ccc1N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 3/20 0.39
PLA2G10 O15496 1/20 0.36
PDE10A Q9Y233 1/20 0.36
ALDH1A1 P00352 5/20 0.35
NOS2 P35228 1/20 0.35
PLA2G7 Q13093 1/20 0.33
TSHR P16473 4/20 0.32
CYP3A4 P08684 4/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
CASP7 P55210 1/20 0.32
HSD17B10 Q99714 1/20 0.32
SMN1; SMN2 Q16637 3/20 0.31
TDP1 Q9NUW8 3/20 0.31
TP53 P04637 2/20 0.31
THRB P10828 1/20 0.31
ALOX15 P16050 1/20 0.31
MAPK1 P28482 1/20 0.31
CD44 P16070 1/20 0.30
ANPEP P15144 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1378405 0.81 PDE10A (0.52) CASP1PLA2G10PDE10AALDH1A1TSHR
SCHEMBL5704935 0.79 CASP1 (0.48) CASP1PLA2G10PDE10AALDH1A1TSHR
SCHEMBL2480042 0.77 CYP3A4 (0.36) CASP1ALDH1A1NOS2PLA2G7TSHR
SCHEMBL7459629 0.77 NOS2 (0.33) CASP1ALDH1A1NOS2PLA2G7CYP3A4
SCHEMBL7458669 0.77 CASP1 (0.31) CASP1ALDH1A1CASP7TP53MEN1
SCHEMBL16887409 0.76 PLA2G10 (0.40) PLA2G10ALDH1A1NOS2NPC1RAB9A
SCHEMBL3338155 0.76 CASP1 (0.46) CASP1PDE10AALDH1A1TSHRCYP3A4
Hydrochloric Acid SCHEMBL7455471 0.76 CYP3A4 (0.35) CASP1ALDH1A1NOS2PLA2G7TSHR
SCHEMBL7800860 0.76 CYP2A6 (0.50) CASP1PDE10AALDH1A1PLA2G7TSHR
Hydrochloric Acid SCHEMBL7807397 0.74 CYP2A6 (0.49) CASP1PDE10AALDH1A1PLA2G7TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0963982-B1 New diaminobenzene derivatives and these componends containing colouring agents WELLA AG (DE) 2002-03-13 EP disclosed
US-6132475-A FOR OXIDATION DYEING OF KERATIN FIBERS; INCLUDES COUPLER AND DEVELOPER, IN WHICH THE DEVELOPER IS A SUBSTITUTED 2-(FURYL, THIENYL, PYRROLYL, OR SELENOPHENE) P-DIAMINOBENZENE DERIVATIVE OF GIVEN FORMULA; COLORFASTNESS, WASHFASTNESS WELLA AKTIENGESELLSCHAFT (DE) 2000-10-17 US disclosed
EP-0963982-A2 New diaminobenzene derivatives and these componends containing colouring agents Wella Aktiengesellschaft (DE) 1999-12-15 EP disclosed