Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 12/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.58 |
| ▸ | HTR1A | P08908 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464563 | 1.00 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL8593528 | 0.88 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL8593309 | 0.85 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL3885649 | 0.85 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL8131142 | 0.83 | ADRA1D (0.65) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL8131145 | 0.83 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BHTR1A | |
| Hydrochloric Acid SCHEMBL8126724 | 0.82 | ADRA1D (0.67) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL29424108 | 0.82 | ADRA1D (0.55) | ADRA1DADRA1AADRA1BHTR1A | |
| Hydrochloric Acid SCHEMBL8126727 | 0.82 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL6981978 | 0.81 | CA2 (0.41) | ADRA1DADRA1AADRA1BHTR1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021442-B1 | 8-AZABICYCLO 3.2.1] OCTANE-3-METHANAMINE DERIVATIVES AS LIGANDS OF D2 AND D3 DOPAMINE AND 5HT1A AND 5HT2 SEROTONIN RECEPTORS | SANOFI SYNTHELABO (FR) | 2002-01-30 | — | — | EP | disclosed |
| US-6221879-B1 | 8-azabicyclo[3.2.1] octane-3-methanamine derivatives as ligands of D2 and D3 dopamine and 5HT1A and 5HT2 serotonin receptors | SANOFI-SYNTHELABO (FR) | 2001-04-24 | — | — | US | disclosed |
| EP-0717739-B1 | 1,4-Benzodioxane derivatives having affinity for D2 receptors and utility in the treatment of psychoses | KNOLL AG (DE) | 2000-03-29 | — | — | EP | disclosed |
| US-5767116-A | TREATING PSYCHOSES | KNOLL ATKIENGESELLSCHAFT (DE) | 1998-06-16 | — | — | US | disclosed |
| EP-0565732-B1 | BENZODIOXANE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1998-01-14 | — | — | EP | disclosed |
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | disclosed |
| EP-0717739-A1 | BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1996-06-26 | — | — | EP | disclosed |
| US-5480905-A | ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1996-01-02 | — | — | US | disclosed |
| US-5474994-A | Treating hypertension, urethral and lower urinary tract contractions | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-12-12 | — | — | US | disclosed |
| WO-1995007274-A1 | BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-03-16 | — | — | WO | disclosed |
| EP-0565732-A1 | BENZODIOXANE DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 1993-10-20 | — | — | EP | disclosed |