Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463607 | 0.95 | KMT2A (0.37) | HSD17B10RAPGEF3KMT2AEGFRMAPT | |
| SCHEMBL7458058 | 0.94 | RAPGEF3 (0.33) | HSD17B10RAPGEF3KMT2AEGFRERBB2 | |
| SCHEMBL7462646 | 0.94 | RAPGEF3 (0.36) | AKR1C3AKR1C2RAPGEF3KMT2AEGFR | |
| SCHEMBL7460951 | 0.93 | RAPGEF3 (0.36) | HSD17B10PPARGRAPGEF3KMT2AMAPT | |
| SCHEMBL7468917 | 0.93 | RAPGEF3 (0.34) | HSD17B10RAPGEF3 | |
| SCHEMBL7463734 | 0.92 | KMT2A (0.43) | RAPGEF3KMT2ABCL2MCL1MAPT | |
| SCHEMBL7460145 | 0.90 | MEN1 (0.33) | KMT2AMAPT | |
| SCHEMBL7460241 | 0.90 | RAPGEF3 (0.34) | RAPGEF3LMNA | |
| SCHEMBL7461643 | 0.89 | RAPGEF3 (0.37) | AKR1C3AKR1C2PPARGRAPGEF3MAPT | |
| SCHEMBL7464601 | 0.88 | PTGER1 (0.33) | HSD17B10AKR1C3AKR1C2KMT2AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0908457-B1 | 3-(1,2-benzisothiazol- and isoxazol-5-Y1)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-y1)-4(3H)-pyrimidinone or thione herbicidal agents | BASF AG (DE) | 2002-11-13 | — | — | EP | disclosed |
| EP-0908457-A1 | 3-(1,2-benzisothiazol- and isoxazol-5-Y1)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-y1)-4(3H)-pyrimidinone or thione herbicidal agents | American Cyanamid Company (US) | 1999-04-14 | — | — | EP | disclosed |