Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.46 |
| ▸ | RXRB | P28702 | 6/20 | 0.46 |
| ▸ | RXRG | P48443 | 4/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ADH5 | P11766 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5211444 | 0.87 | CYP11B1 (0.42) | RXRARXRBRXRGALDH1A1HPGD | |
| SCHEMBL7457881 | 0.86 | KDM4E (0.45) | TSHRALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL7459279 | 0.85 | PKM (0.38) | TSHRMAPTPKMNOTUMLMNA | |
| SCHEMBL1361930 | 0.84 | NOTUM (0.40) | NOTUMADH5CD38 | |
| SCHEMBL7461986 | 0.80 | RXRA (0.46) | RXRARXRBRXRGTSHRALDH1A1 | |
| SCHEMBL7468386 | 0.80 | RXRA (0.48) | RXRARXRBRXRGTSHRALDH1A1 | |
| SCHEMBL7459313 | 0.78 | NOTUM (0.37) | ALDH1A1MAPTNOTUMLMNACD38 | |
| SCHEMBL6606347 | 0.78 | RXRA (0.47) | RXRARXRBRXRGTSHRALDH1A1 | |
| SCHEMBL7466864 | 0.78 | RXRA (0.48) | RXRARXRBRXRGTSHRALDH1A1 | |
| SCHEMBL5207078 | 0.78 | CHRM1 (0.37) | ALDH1A1HPGDMAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498179-B1 | SUCH AS 4-(4-CHLOROPHENYL)-5-(3-(2-METHOXYPHENOXY)PROPYL)-2-(2-METHYL-1 -IMIDAZOLYL)OXAZOLE; INSULIN SECERTION PROMOTING AND BLOOD SUGAR DEPRESSING EFFECT; DIABETES; LOW TOXICITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-0891340-B1 | OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6177452-B1 | ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-23 | — | — | US | disclosed |