Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ADH5 | P11766 | 5/20 | 0.39 |
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.34 |
| ▸ | CYP27B1 | O15528 | 2/20 | 0.34 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468394 | 0.80 | MAOA (0.42) | MAOAADRA1ANOTUMCNR1CNR2 | |
| SCHEMBL7461994 | 0.80 | ALDH1A1 (0.42) | MAOAADRA1ASMN1; SMN2LMNACYP3A4 | |
| SCHEMBL6606357 | 0.79 | MAOA (0.39) | MAOAADRA1A | |
| SCHEMBL7462934 | 0.78 | MAOA (0.38) | MAOAADRA1ACNR1SMN1; SMN2CYP2D6 | |
| SCHEMBL7466867 | 0.78 | MAOA (0.41) | MAOAADRA1ACNR1TDP1 | |
| SCHEMBL7456593 | 0.77 | CNR1 (0.42) | MAOAADRA1ACNR1NPSR1TDP1 | |
| SCHEMBL7463542 | 0.77 | MAOA (0.39) | MAOAADRA1ASMN1; SMN2LMNACYP3A4 | |
| SCHEMBL7459960 | 0.77 | MAOA (0.48) | MAOAADRA1ACYP3A4CYP2D6 | |
| SCHEMBL7468230 | 0.77 | MAOA (0.37) | MAOAADRA1ANPSR1 | |
| SCHEMBL7453586 | 0.77 | MAPT (0.38) | MAOAADRA1ACNR1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498179-B1 | SUCH AS 4-(4-CHLOROPHENYL)-5-(3-(2-METHOXYPHENOXY)PROPYL)-2-(2-METHYL-1 -IMIDAZOLYL)OXAZOLE; INSULIN SECERTION PROMOTING AND BLOOD SUGAR DEPRESSING EFFECT; DIABETES; LOW TOXICITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-0891340-B1 | OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6177452-B1 | ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-23 | — | — | US | disclosed |