Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | PRKCA | P17252 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | BCR | P11274 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 3/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475710 | 0.86 | ABL1 (0.71) | ABL1PRKCAEGFRPRKCDBCR | |
| SCHEMBL7466611 | 0.85 | RAB9A (0.63) | ABL1NPC1RAB9ABCRKIT | |
| SCHEMBL13185630 | 0.81 | IKBKB (0.60) | ABL1PRKCAEGFRPRKCDNPC1 | |
| SCHEMBL7465536 | 0.81 | ABL1 (0.54) | ABL1PRKCAEGFRPRKCDNPC1 | |
| SCHEMBL6957436 | 0.78 | ZAP70 (0.66) | PRKCAEGFRPRKCDIKBKBCHUK | |
| SCHEMBL7459060 | 0.77 | NPC1 (0.46) | ABL1PRKCAEGFRPRKCDNPC1 | |
| SCHEMBL7469906 | 0.77 | IKBKB (0.63) | ABL1PRKCAEGFRPRKCDNPC1 | |
| SCHEMBL10346581 | 0.76 | JAK2 (0.70) | EGFRJAK2JAK3MAPK8MAPK10 | |
| SCHEMBL7475790 | 0.76 | IKBKB (0.64) | NPC1RAB9AIKBKBCHUK | |
| SCHEMBL7460307 | 0.75 | SYK (0.55) | ABL1PRKCABCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |