Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.64 |
| ▸ | DKK1 | O94907 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | CDK2 | P24941 | 15/20 | 0.48 |
| ▸ | CDK4 | P11802 | 9/20 | 0.48 |
| ▸ | CDK1 | P06493 | 5/20 | 0.48 |
| ▸ | CDK7 | P50613 | 5/20 | 0.48 |
| ▸ | CDK9 | P50750 | 5/20 | 0.48 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 3/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476601 | 0.83 | IKBKB (0.70) | IKBKBDKK1GSK3BCDK2CDK4 | |
| SCHEMBL13167604 | 0.81 | GSK3B (0.64) | IKBKBDKK1GSK3BCDK2CDK4 | |
| SCHEMBL7475925 | 0.79 | IKBKB (0.65) | IKBKBDKK1GSK3BAURKAPLK1 | |
| SCHEMBL7465536 | 0.78 | ABL1 (0.54) | IKBKBNPC1RAB9ASYKSRC | |
| SCHEMBL13185630 | 0.78 | IKBKB (0.60) | IKBKBGSK3BNPC1RAB9APLK1 | |
| SCHEMBL7459060 | 0.77 | NPC1 (0.46) | CDK2CDK4CDK1CDK7CDK9 | |
| SCHEMBL7460307 | 0.77 | SYK (0.55) | SYK | |
| SCHEMBL7464633 | 0.76 | ABL1 (0.51) | IKBKBNPC1RAB9ACHUK | |
| SCHEMBL7469906 | 0.76 | IKBKB (0.63) | IKBKBNPC1RAB9APLK1SYK | |
| SCHEMBL7473582 | 0.76 | CDK2 (0.65) | IKBKBDKK1GSK3BCDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | disclosed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |