Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | SELP | P16109 | 3/20 | 0.44 |
| ▸ | SELL | P14151 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3443849 | 0.97 | L3MBTL1 (0.51) | L3MBTL1AKR1C1SIGMAR1HTTLMNA | |
| SCHEMBL1465128 | 0.95 | SIGMAR1 (0.50) | L3MBTL1AKR1C1SIGMAR1HTTLMNA | |
| SCHEMBL30683848 | 0.85 | L3MBTL1 (0.54) | L3MBTL1SIGMAR1HTTLMNAKMT2A | |
| SCHEMBL7457587 | 0.85 | L3MBTL1 (0.54) | L3MBTL1SIGMAR1HTTLMNAKMT2A | |
| SCHEMBL21034068 | 0.83 | L3MBTL1 (0.49) | L3MBTL1AKR1C1SIGMAR1HTTLMNA | |
| SCHEMBL30039438 | 0.83 | L3MBTL1 (0.49) | L3MBTL1AKR1C1SIGMAR1HTTLMNA | |
| SCHEMBL11642260 | 0.82 | L3MBTL1 (0.50) | L3MBTL1AKR1C1KMT2AMEN1ALDH1A1 | |
| SCHEMBL16132817 | 0.82 | HDAC4 (0.65) | L3MBTL1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL8110630 | 0.81 | SIGMAR1 (0.47) | L3MBTL1SIGMAR1HTTLMNAAPP | |
| SCHEMBL21034824 | 0.81 | SIGMAR1 (0.47) | L3MBTL1SIGMAR1HTTLMNAAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165082-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-06-12 | — | — | EP | disclosed |
| US-6358956-B1 | IMIDAZOLYLALKYL-1-PIPERAZINE DERIVATIVES; FARNESYL-PROTEIN AND GERANYLGERANYL TRANSFERASE INHIBITORS; ANTICARCINOGENIC AGENTS | MERCK & CO., INC. | 2002-03-19 | — | — | US | disclosed |
| EP-1165082-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000051611-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-09-08 | — | — | WO | disclosed |