Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170029 | 0.93 | SIGMAR1 (0.52) | DRD2SIGMAR1HTR1A | |
| SCHEMBL6171250 | 0.90 | SIGMAR1 (0.52) | DRD2SIGMAR1HTR1A | |
| SCHEMBL7472426 | 0.89 | SIGMAR1 (0.51) | DRD2SIGMAR1 | |
| SCHEMBL7472293 | 0.88 | SIGMAR1 (0.49) | DRD2SIGMAR1HTR1A | |
| SCHEMBL7475313 | 0.88 | DRD2 (0.37) | DRD2HTR1A | |
| SCHEMBL7470561 | 0.87 | SIGMAR1 (0.49) | DRD2SIGMAR1HTR1A | |
| SCHEMBL7472651 | 0.85 | SIGMAR1 (0.47) | DRD2SIGMAR1HTR1A | |
| Piclozotan SCHEMBL30249060 | 0.85 | SIGMAR1 (0.54) | DRD2SIGMAR1HTR1A | |
| Piclozotan SCHEMBL562627 | 0.85 | SIGMAR1 (0.54) | DRD2SIGMAR1HTR1A | |
| Piclozotan SCHEMBL29379540 | 0.85 | SIGMAR1 (0.54) | DRD2SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755930-B1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LTD (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-6337397-B1 | A BENZOXAZEPINE DERIVATIVE FOR TREATMENT OF ANXIETY NEUROSIS, PHOBIAS, OBSESSIVE-COMPULSIVE DISORDERS, SCHIZOPHRENIA, POST-CARDIAC TRAUMA STRESS DISORDERS, DEPRESSION DISORDERS, PSYCHOSOMATIC DISORDERS AND OTHER PSYCHONEUROTIC DISORDERS, | SUNTORY LIMITED (JP) | 2002-01-08 | — | — | US | disclosed |
| US-6187769-B1 | Benzoxazepine derivatives and their salts and medicaments containing the same | SUNTORY LIMITED (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0755930-A1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |