Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | FAAH | O00519 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20067671 | 0.90 | NPC1 (0.67) | KDM4EALDH1A1FAAHSMN1; SMN2NPC1 | |
| SCHEMBL6631322 | 0.90 | NPC1 (0.67) | KDM4EALDH1A1FAAHSMN1; SMN2NPC1 | |
| SCHEMBL6587099 | 0.88 | FAAH (0.62) | KDM4EALDH1A1FAAHSMN1; SMN2TP53 | |
| SCHEMBL7096012 | 0.85 | KDM4E (0.69) | KDM4EALDH1A1FAAHSMN1; SMN2NPC1 | |
| SCHEMBL3811686 | 0.84 | ALOX5 (0.69) | KDM4ESMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL7470383 | 0.84 | KMT2A (0.67) | SMN1; SMN2NPC1RAB9ACYP2C9CYP2C19 | |
| SCHEMBL2897923 | 0.84 | KDM4E (0.77) | KDM4EALDH1A1FAAHSMN1; SMN2CYP2C9 | |
| SCHEMBL10729724 | 0.84 | KDM4E (0.77) | KDM4EALDH1A1FAAHSMN1; SMN2CYP2C9 | |
| SCHEMBL7313251 | 0.83 | KDM4E (0.77) | KDM4EALDH1A1FAAHSMN1; SMN2NPC1 | |
| SCHEMBL7091190 | 0.83 | KDM4E (0.68) | KDM4EALDH1A1FAAHSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |