SCHEMBL7465246

SCHEMBL7465246

CCc1csc(CO)c1NC(=O)OC(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PI4KB Q9UBF8 1/20 0.37
ATR Q13535 1/20 0.36
LCK P06239 5/20 0.35
SREBF2 Q12772 1/20 0.34
CYP17A1 P05093 1/20 0.34
CA1 P00915 2/20 0.33
CA2 P00918 1/20 0.33
CTSL P07711 1/20 0.33
CTSS P25774 1/20 0.33
CTSK P43235 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
METAP1 P53582 1/20 0.33
CA12 O43570 1/20 0.33
CA9 Q16790 1/20 0.33
PSMB8 P28062 1/20 0.33
SIRT1 Q96EB6 1/20 0.32
ABCB1 P08183 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22774841 0.91 ATR (0.38) PI4KBATRLCKSREBF2CYP17A1
SCHEMBL26456528 0.79 PI4KB (0.40) PI4KBATRLCKCYP17A1CA1
SCHEMBL23960309 0.78 ATR (0.41) PI4KBATRLCKCYP17A1CA1
SCHEMBL10437433 0.73 NLRP3 (0.56) ATRLCKTDP1
SCHEMBL5919144 0.73 MEN1 (0.53) ABCB1
SCHEMBL15390593 0.72 NQO2 (0.45) ATRLCKCYP17A1CA1CTSS
SCHEMBL23960254 0.71 ATR (0.40) PI4KBATRLCKCYP17A1CA1
SCHEMBL3030230 0.71 LCK (0.44) ATRLCKCYP17A1
SCHEMBL25179953 0.71 METAP1 (0.38) PI4KBATRLCKSREBF2CYP17A1
SCHEMBL9291305 0.70 MEN1 (0.44) PI4KBATRCA1CA2CTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1078209-C Substituted thiophene derivative and plant disease prevention and control agent containing same MITSUI TOATSU CHEMICALS (JP) 2002-01-23 CN disclosed
EP-0737682-B1 Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient MITSUI CHEMICALS INC (JP) 2002-01-09 EP disclosed
CN-1061657-C Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient MITSUI TOATSU CHEMICALS (JP) 2001-02-07 CN disclosed
CN-1185437-A Substituted thiophene derivative and plant disease prevention and control agent containing same MITSUI TOATSU CHEMICALS (JP) 1998-06-24 CN disclosed
US-5747518-A EFFECTIVE AGAINST CHEMICAL RESISTANT FUNGI; NONPHYTOTOXIC TO CROPS MITSUI TOATSU CHEMICALS, INC. (JP) 1998-05-05 US disclosed
CN-1146993-A Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient MITSUI TOATSU CHEMICALS (JP) 1997-04-09 CN disclosed
EP-0737682-A1 Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1996-10-16 EP disclosed