SCHEMBL7465305

SCHEMBL7465305

CC(O[Si](C)(C)C(C)(C)C)C1Oc2c(Cl)cc(Cl)cc2NC1=O

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 2/20 0.31
CES1 P23141 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7463464 0.81 HSD17B10 (0.44) BRD4
SCHEMBL4967477 0.81 BRD4 (0.41) BRD4CES1
SCHEMBL4971251 0.81 BRD4 (0.41) BRD4CES1
SCHEMBL4970185 0.81 BRD4 (0.41) BRD4CES1
SCHEMBL7465296 0.75 MEN1 (0.33) BRD4
SCHEMBL7465292 0.73
SCHEMBL7472419 0.73 PARP1 (0.49) BRD4
SCHEMBL8601455 0.71 BRD4 (0.35) BRD4
SCHEMBL7468490 0.71 BRD4 (0.42) BRD4
SCHEMBL5671638 0.70 PARP1 (0.44) CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869949-B1 BENZOXAZINE ANTIMICROBIAL AGENTS ORTHO MCNEIL PHARM INC (US) 2002-12-18 EP disclosed
US-5854242-A Benzoxazine antimicrobial agents ORTHO PHARMACEUTICAL CORPORATION (US) 1998-12-29 US disclosed
US-5696117-A BACTERICIDE ORTHO PHARMACEUTICAL CORPORATION (US) 1997-12-09 US disclosed