Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 13/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | BRD2 | P25440 | 2/20 | 0.63 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.63 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.63 |
| ▸ | PDE4A | P27815 | 2/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19090444 | 0.87 | BRD4 (1.00) | BRD4MEN1KMT2ABRD2BRD3 | |
| SCHEMBL7454403 | 0.85 | PDE4A (0.61) | BRD4MEN1KMT2ABRD2BRD3 | |
| SCHEMBL556233 | 0.85 | BRD4 (0.82) | BRD4MEN1KMT2ABRD2BRD3 | |
| SCHEMBL6661580 | 0.82 | BRD4 (0.51) | BRD4MEN1KMT2ABRD2BRD3 | |
| SCHEMBL554932 | 0.82 | BRD4 (0.81) | BRD4MEN1KMT2ABRD2BRD3 | |
| SCHEMBL555712 | 0.81 | BRD4 (0.71) | BRD4MEN1KMT2ABRD2BRD3 | |
| SCHEMBL9351810 | 0.80 | BRD4 (0.74) | BRD4MEN1KMT2ABRD2BRD3 | |
| SCHEMBL7607643 | 0.80 | PDE4A (0.74) | BRD4MEN1KMT2ABRD2BRD3 | |
| SCHEMBL6665240 | 0.80 | BRD4 (0.48) | BRD4MEN1KMT2ABRD2BRD3 | |
| SCHEMBL7464093 | 0.79 | MAPK1 (0.57) | BRD4MEN1KMT2ABRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771813-B1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AG (DE) | 2002-01-16 | — | — | EP | disclosed |
| US-5728686-A | TREATMENT OF MUSCULAR DYSTROPHY | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-17 | — | — | US | disclosed |
| EP-0771813-A1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-07 | — | — | EP | disclosed |
| EP-0528164-B1 | Use of xanthine derivatives for the manufacture of a medicament for the treatment of secondary nerve cell damages and function disorders after head-brain-traumata | HOECHST AG (DE) | 1996-05-29 | — | — | EP | disclosed |
| US-5409935-A | Inhibit formation of free radicals | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-25 | — | — | US | disclosed |
| EP-0528164-A2 | Use of xanthine derivatives for the manufacture of a medicament for the treatment of secondary nerve cell damages and function disorders after head-brain-traumata | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-24 | — | — | EP | disclosed |