Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 2/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6661580 | 0.81 | BRD4 (0.51) | BRD4KDM4ELMNAPOLBMAPK1 | |
| SCHEMBL7465479 | 0.80 | BRD4 (0.76) | BRD4KDM4ELMNAPOLBMAPK1 | |
| SCHEMBL7464093 | 0.77 | MAPK1 (0.57) | BRD4KDM4ELMNAPOLBMAPK1 | |
| SCHEMBL7454403 | 0.76 | PDE4A (0.61) | BRD4KDM4ELMNAPOLBMAPK1 | |
| SCHEMBL555928 | 0.71 | BRD4 (0.62) | BRD4KDM4ELMNAPOLBMAPK1 | |
| SCHEMBL22105440 | 0.70 | BRD4 (0.62) | BRD4KDM4ELMNAPOLBMAPK1 | |
| SCHEMBL28749938 | 0.69 | LMNA (0.64) | BRD4KDM4ELMNAPOLBMAPK1 | |
| SCHEMBL5773292 | 0.68 | BRD4 (0.61) | BRD4KDM4ELMNAPOLBMAPK1 | |
| SCHEMBL27504906 | 0.68 | LMNA (0.76) | BRD4KDM4ELMNAPOLBMAPK1 | |
| SCHEMBL7454607 | 0.67 | GDA (0.54) | BRD4MEN1KMT2APDE4AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257552-B1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | AVENTIS PHARMA SA (FR) | 2004-08-18 | — | — | EP | disclosed |
| EP-1257552-A1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | Aventis Pharma S.A. (FR) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001060824-A1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | AVENTIS PHARMA S.A. (FR) | 2001-08-23 | — | — | WO | disclosed |