Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406732 | 0.85 | HDAC8 (0.47) | HDAC8HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL7400657 | 0.82 | CYP1A2 (0.48) | HDAC8HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL19326364 | 0.81 | FOLH1 (0.58) | HDAC8HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL19326365 | 0.80 | MME (0.50) | HDAC8HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL22510729 | 0.78 | HDAC8 (0.47) | HDAC8HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL28415536 | 0.78 | MME (0.56) | HDAC8HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL10241691 | 0.78 | MME (0.56) | HDAC8HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL19321589 | 0.77 | HDAC8 (0.46) | HDAC8HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL10656676 | 0.76 | CA2 (0.40) | ACE | |
| SCHEMBL10656672 | 0.76 | CA2 (0.40) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790982-B1 | METHODS OF SYNTHESIS OF PEPTIDYL ARGININALS | CORVAS INT INC (US) | 2002-02-27 | — | — | EP | disclosed |
| US-5731413-A | Method of synthesis of peptidyl aldehydes | CORVAS INTERNATIONAL, INC. (US) | 1998-03-24 | — | — | US | disclosed |
| US-5514777-A | Methods of synthesis of peptidyl argininals | CORVAS INTERNATIONAL, INC. (US) | 1996-05-07 | — | — | US | disclosed |