Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000424 | 0.86 | TP53 (0.48) | LMNATP53HTT | |
| SCHEMBL9593487 | 0.82 | LMNA (0.49) | LMNATP53HTTMAPTCNR1 | |
| SCHEMBL7471569 | 0.80 | KDM4E (0.39) | LMNA | |
| SCHEMBL16956351 | 0.80 | ALDH1A1 (0.36) | LMNATP53HTTMAPTCNR2 | |
| SCHEMBL5000481 | 0.79 | TP53 (0.52) | LMNATP53HTT | |
| SCHEMBL11852189 | 0.78 | MAPT (0.44) | LMNATP53HTTMAPT | |
| SCHEMBL11845767 | 0.78 | MAPT (0.44) | LMNATP53HTTMAPT | |
| SCHEMBL11852040 | 0.78 | MAPT (0.44) | LMNATP53HTTMAPT | |
| SCHEMBL11480155 | 0.77 | MAPT (0.41) | LMNATP53HTTMAPT | |
| SCHEMBL11859233 | 0.77 | MAPT (0.41) | LMNATP53HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244617-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047875-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-07-05 | — | — | WO | disclosed |