Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856019 | 0.87 | KDM4E (0.38) | KDM4EALDH1A1HTTATMHRH3 | |
| SCHEMBL9065677 | 0.85 | KDM4E (0.37) | KDM4EALDH1A1HTTATMHRH3 | |
| SCHEMBL9066008 | 0.85 | KDM4E (0.37) | KDM4EALDH1A1HTTATMHRH3 | |
| SCHEMBL3132700 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1HTTATMHRH3 | |
| SCHEMBL5796273 | 0.82 | KDM4E (0.35) | KDM4EALDH1A1HTTATM | |
| SCHEMBL11376925 | 0.80 | KDM4E (0.34) | KDM4E | |
| SCHEMBL9787963 | 0.80 | KDM4E (0.34) | KDM4E | |
| SCHEMBL4123213 | 0.79 | — | — | |
| SCHEMBL10616726 | 0.78 | LPL (0.33) | KDM4EALDH1A1 | |
| SCHEMBL9788005 | 0.78 | LPL (0.33) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276035-A | Central nervous system disorders; Parkinson's disease; antidepressant and dopaminergic agent | NOVO NORDISK A/S (DK) | 1994-01-04 | — | — | US | disclosed |
| EP-0541617-A1 | 1,4-DISUBSTITUTED PIPERAZINES. | NOVO NORDISK AS (DK) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992001679-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1992-02-06 | — | — | WO | disclosed |