Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.45 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.45 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.45 |
| ▸ | PREP | P48147 | 2/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710151 | 0.85 | POLB (0.49) | HTTSMN1; SMN2LMNAGAAHRH4 | |
| SCHEMBL15132766 | 0.81 | SMN1; SMN2 (0.67) | HTTSMN1; SMN2HRH4POLB | |
| SCHEMBL30980576 | 0.80 | LMNA (0.64) | HTTSMN1; SMN2LMNAGAATGM2 | |
| SCHEMBL28473741 | 0.78 | SMN1; SMN2 (0.56) | HTTSMN1; SMN2LMNAHRH4POLB | |
| SCHEMBL30980778 | 0.77 | HTT (0.44) | HTTSMN1; SMN2LMNATGM2DPP8 | |
| SCHEMBL319161 | 0.77 | HTT (1.00) | HTTSMN1; SMN2LMNATGM2KEAP1 | |
| SCHEMBL18254066 | 0.76 | HTT (0.81) | HTTSMN1; SMN2LMNATGM2DPP8 | |
| SCHEMBL24461095 | 0.76 | POLB (0.44) | LMNAHRH4ANPEPPOLBSLC1A3 | |
| SCHEMBL29440183 | 0.76 | ATM (0.48) | LMNAHRH4POLB | |
| SCHEMBL14295143 | 0.76 | HTT (0.67) | HTTSMN1; SMN2LMNAGAATGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711768-B1 | BENZIMIDAZOLE DERIVATIVE | MITSUI CHEMICALS INC (JP) | 2002-02-13 | — | — | EP | disclosed |
| US-5852011-A | Benzimidazole derivatives | MITSUI CHEMICALS, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0711768-A1 | BENZIMIDAZOLE DERIVATIVE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-15 | — | — | EP | disclosed |