SCHEMBL7466633

SCHEMBL7466633

Clc1cc(Cl)c2c(Oc3cccc(Br)c3)ccnc2c1

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.54
KDR P35968 1/20 0.39
LMNA P02545 2/20 0.36
MAPT P10636 2/20 0.36
ALDH1A1 P00352 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
SLC6A4 P31645 1/20 0.36
KDM4E B2RXH2 1/20 0.36
POLB P06746 1/20 0.36
KMT2A Q03164 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HTT P42858 1/20 0.35
RAB9A P51151 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ABCG2 Q9UNQ0 1/20 0.35
MAOB P27338 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7460965 0.84 PLAU (0.46) EGFRLMNAALDH1A1SMN1; SMN2KMT2A
SCHEMBL7532122 0.82 NR4A2 (0.40) LMNAMAPTSMN1; SMN2TDP1KMT2A
SCHEMBL7463496 0.81 EGFR (0.64) EGFRKDRLMNAMAPTSMN1; SMN2
Quinoxyfen SCHEMBL22257 0.78 RET (0.42) EGFRKDRLMNAMAPTSMN1; SMN2
Quinoxyfen SCHEMBL28247243 0.78 RET (0.42) EGFRKDRLMNAMAPTSMN1; SMN2
Quinoxyfen SCHEMBL7471425 0.77 RET (0.41) EGFRKDRLMNAMAPTSMN1; SMN2
Quinoxyfen SCHEMBL1974400 0.77 RET (0.41) EGFRKDRLMNAMAPTSMN1; SMN2
SCHEMBL7461330 0.76 RHEB (0.46) EGFRMAPTALDH1A1TDP1SLC6A4
SCHEMBL7460172 0.75 MERTK (0.42) EGFRMAPTSLC6A4KMT2AL3MBTL1
SCHEMBL7050110 0.72 EGFR (0.41) EGFRKDRSLC6A4KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP claimed
US-5145843-A For plants DOWELANCO (US) 1992-09-08 US claimed
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP disclosed