Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.69 |
| ▸ | MMP9 | P14780 | 5/20 | 0.69 |
| ▸ | MMP1 | P03956 | 3/20 | 0.69 |
| ▸ | MMP3 | P08254 | 3/20 | 0.69 |
| ▸ | MMP13 | P45452 | 3/20 | 0.69 |
| ▸ | MMP7 | P09237 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | CTSS | P25774 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.54 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 2/20 | 0.51 |
| ▸ | MMP12 | P39900 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062885 | 1.00 | MMP2 (0.69) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7469215 | 1.00 | MMP2 (0.69) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7066619 | 0.87 | MMP9 (0.71) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL11351046 | 0.87 | MMP9 (0.71) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL3969625 | 0.87 | MMP9 (0.71) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL5191083 | 0.86 | MMP2 (0.70) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL6561338 | 0.86 | MMP2 (0.70) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL15251807 | 0.86 | MMP2 (0.70) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL21067512 | 0.85 | MMP2 (0.82) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL21067511 | 0.85 | MMP2 (0.82) | MMP2MMP9MMP1MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874836-B1 | SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | disclosed |
| US-6297247-B1 | Sulfonamide inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY | 2001-10-02 | — | — | US | disclosed |
| US-6153612-A | Sulfonamide inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| US-5977141-A | Sulfonamide inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0874836-A1 | SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997019068-A1 | SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1997-05-29 | — | — | WO | disclosed |