Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.69 |
| ▸ | HTR2A | P28223 | 4/20 | 0.65 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.65 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 6/20 | 0.58 |
| ▸ | HTR1D | P28221 | 4/20 | 0.58 |
| ▸ | HTR1B | P28222 | 4/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28117188 | 0.95 | SLC6A4 (0.71) | SLC6A4HTR2ATRPM8GPR84GFER | |
| SCHEMBL12464834 | 0.89 | HTR2A (0.71) | SLC6A4HTR2ATRPM8GPR84GFER | |
| SCHEMBL8808469 | 0.86 | SLC6A4 (0.67) | SLC6A4HTR2ATRPM8GPR84GFER | |
| SCHEMBL16433301 | 0.84 | SLC6A4 (0.65) | SLC6A4HTR2ATRPM8GPR84GFER | |
| SCHEMBL15676249 | 0.84 | HTR2A (0.69) | SLC6A4HTR2ATRPM8GPR84GFER | |
| SCHEMBL891985 | 0.83 | SLC6A4 (0.67) | SLC6A4HTR2ATRPM8GPR84GFER | |
| SCHEMBL892282 | 0.83 | SLC6A4 (0.67) | SLC6A4HTR2ATRPM8GPR84GFER | |
| SCHEMBL892989 | 0.83 | HTR2A (0.82) | SLC6A4HTR2ATRPM8GPR84GFER | |
| SCHEMBL10119751 | 0.82 | GPR84 (0.73) | SLC6A4HTR2ATRPM8GPR84GFER | |
| SCHEMBL6978810 | 0.81 | SLC6A4 (0.69) | SLC6A4HTR2AHTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058678-B1 | METAL-CATALYZED ARYLATIONS AND VINYLATIONS OF HYDRAZINES, HYDRAZONES, HYDROXYLAMINES AND OXIMES | MASSACHUSETTS INST TECHNOLOGY (US) | 2002-12-11 | — | — | EP | disclosed |
| US-6465693-B2 | TRANSITION METAL CATALYZED ARYLATION OR VINYLATION; COMBINATORIAL CHEMISTRY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-10-15 | — | — | US | disclosed |
| US-20010031894-A1 | Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates | BUCHWALD STEPHEN L (US) | 2001-10-18 | — | — | US | disclosed |
| US-6235936-B1 | TRANSITION METAL CATALYST FOR ARYLATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2001-05-22 | — | — | US | disclosed |
| EP-1058678-A2 | METAL-CATALYZED ARYLATIONS AND VINYLATIONS OF HYDRAZINES, HYDRAZONES, HYDROXYLAMINES AND OXIMES | Massachusetts Institute of Technology (US) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999043643-A2 | METAL-CATALYZED ARYLATIONS AND VINYLATIONS OF HYDRAZINES, HYDRAZONES, HYDROXYLAMINES AND OXIMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010031894-A1 | Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates | IDO1, IDO2, AHR | SLC6A4 563/4885HTR2A 585/4885TRPM8 3988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.