Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 7/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | CCR1 | P32246 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | CCR3 | P51677 | 2/20 | 0.41 |
| ▸ | PLD2 | O14939 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465649 | 0.94 | MCHR1 (0.46) | MCHR1DRD3SLC6A2SLC6A4KDM4E | |
| SCHEMBL7459832 | 0.94 | MCHR1 (0.51) | MCHR1DRD3SLC6A2SLC6A4KDM4E | |
| SCHEMBL7460453 | 0.94 | CCR1 (0.44) | MCHR1DRD3DRD2HTR1AHTR2C | |
| SCHEMBL7459200 | 0.93 | MCHR1 (0.45) | MCHR1DRD3SLC6A2SLC6A4KDM4E | |
| SCHEMBL7455892 | 0.92 | MCHR1 (0.43) | MCHR1DRD3DRD2HTR1AHTR2C | |
| SCHEMBL7458988 | 0.92 | MCHR1 (0.48) | MCHR1DRD3CCR1CCR3 | |
| SCHEMBL7470930 | 0.91 | MCHR1 (0.42) | MCHR1DRD3 | |
| SCHEMBL7466978 | 0.91 | KDM4E (0.46) | MCHR1DRD3KDM4EDRD2HTR2A | |
| SCHEMBL7460423 | 0.90 | MCHR1 (0.56) | MCHR1DRD3SLC6A2SLC6A4KDM4E | |
| SCHEMBL7463847 | 0.86 | DRD3 (0.48) | MCHR1DRD3SLC6A2SLC6A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1219294-A1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2002-07-03 | — | — | EP | claimed |
| EP-1219294-A1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2002-07-03 | — | — | EP | disclosed |