SCHEMBL7467451

SCHEMBL7467451

CCOC(=O)C1=C(C)NC(CSC(=O)CC)=C(C(=O)OCC)C1c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 0.67
CACNA1C Q13936 11/20 0.55
CACNA1D Q01668 11/20 0.55
CACNA1F O60840 10/20 0.55
CACNA1S Q13698 10/20 0.55
MEN1 O00255 3/20 0.52
MAPT P10636 3/20 0.52
KMT2A Q03164 3/20 0.52
LMNA P02545 2/20 0.52
ALDH1A1 P00352 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
ABCC1 P33527 1/20 0.52
HIF1A Q16665 3/20 0.52
CYP1A2 P05177 2/20 0.52
CYP3A4 P08684 2/20 0.52
CYP2C9 P11712 2/20 0.52
CYP2C19 P33261 2/20 0.52
POLB P06746 1/20 0.52
MAPK1 P28482 1/20 0.52
GPR55 Q9Y2T6 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9808344 0.88 CACNA1F (0.74) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S
SCHEMBL10816971 0.87 ADORA3 (0.75) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S
SCHEMBL7464524 0.86 ADORA3 (0.67) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S
SCHEMBL11520718 0.85 ADORA3 (0.75) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S
SCHEMBL3027749 0.84 ADORA3 (0.90) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S
SCHEMBL7237214 0.82 ADORA3 (0.82) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S
SCHEMBL7531635 0.82 ADORA3 (0.62) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S
SCHEMBL7467445 0.82 CACNA1C (0.60) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S
SCHEMBL7529161 0.82 ADORA3 (0.61) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S
SCHEMBL7159073 0.80 ADORA3 (1.00) ADORA3CACNA1CCACNA1DCACNA1FCACNA1S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0233228-A1 PHARMACEUTICALLY ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1987-08-26 EP disclosed
WO-1987000836-A1 PHARMACEUTICALLY ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDROPYRIDINES BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) 1987-02-12 WO disclosed