SCHEMBL7529161

SCHEMBL7529161

CCOC(=O)C1=C(C)NC(CSCCc2ccccc2)=C(C(=O)OCC)C1c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 0.61
CACNA1D Q01668 9/20 0.55
CACNA1F O60840 8/20 0.54
CACNA1S Q13698 8/20 0.54
CACNA1C Q13936 8/20 0.54
MEN1 O00255 3/20 0.53
MAPT P10636 3/20 0.53
KMT2A Q03164 3/20 0.53
LMNA P02545 2/20 0.53
CACNA1B Q00975 1/20 0.53
ALDH1A1 P00352 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
PDE1C Q14123 1/20 0.52
HIF1A Q16665 3/20 0.50
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
POLB P06746 1/20 0.50
MAPK1 P28482 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9875241 0.90 CACNA1F (0.69) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL7464524 0.85 ADORA3 (0.67) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL7529154 0.85 CACNA1C (0.57) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL10611864 0.84 ADORA3 (0.71) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL7561682 0.84 ADORA3 (0.57) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL10816971 0.83 ADORA3 (0.75) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL9808352 0.83 CACNA1C (0.71) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL7531635 0.82 ADORA3 (0.62) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL7470988 0.82 CACNA1F (0.77) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C
SCHEMBL7467451 0.82 ADORA3 (0.67) ADORA3CACNA1DCACNA1FCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0233228-A1 PHARMACEUTICALLY ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1987-08-26 EP disclosed
WO-1987000836-A1 PHARMACEUTICALLY ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDROPYRIDINES BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) 1987-02-12 WO disclosed