Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469920 | 0.86 | TSHR (0.47) | L3MBTL1MAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL15847129 | 0.85 | L3MBTL1 (0.51) | L3MBTL1MAPTCYP1A2CYP3A4TSHR | |
| SCHEMBL18184934 | 0.82 | CA12 (0.47) | L3MBTL1MAPTCYP1A2CYP3A4TSHR | |
| SCHEMBL27736616 | 0.78 | CNR1 (0.50) | L3MBTL1MAPTCYP1A2CYP3A4TSHR | |
| SCHEMBL27736617 | 0.78 | CNR1 (0.50) | L3MBTL1MAPTCYP1A2CYP3A4TSHR | |
| SCHEMBL7009768 | 0.76 | DAO (0.46) | KDM4EKMT2ALMNA | |
| SCHEMBL7470990 | 0.75 | AURKA (0.32) | MAPTKMT2AMEN1ACHE | |
| SCHEMBL2601112 | 0.74 | ALDH1A1 (0.60) | L3MBTL1MAPTCYP1A2CYP3A4TSHR | |
| SCHEMBL19334711 | 0.74 | ALDH1A1 (0.60) | L3MBTL1MAPTCYP1A2CYP3A4TSHR | |
| SCHEMBL18184933 | 0.74 | L3MBTL1 (0.42) | L3MBTL1MAPTCYP1A2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906279-B1 | PYRROLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-6136844-A | ANTIINFLAMMATORY AGENT; AUTOIMMUNE DISEASE | SYNTEX (U.S.A.) INC. (US) | 2000-10-24 | — | — | US | disclosed |
| US-6127402-A | AN INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE AND ARE ANTI-INFLAMMATORY AND ANALGESIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 2000-10-03 | — | — | US | disclosed |
| US-5952368-A | AN INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE, ANTIINFLAMMATORY AND ANALGESIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0906279-A1 | NOVEL PYRROLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997046524-A1 | NOVEL PYRROLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-11 | — | — | WO | disclosed |