Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 8/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.42 |
| ▸ | DHFR | P00374 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463419 | 0.86 | ADORA1 (0.59) | ADORA1ADORA2ADHFRIDO1ABL1 | |
| SCHEMBL7471062 | 0.83 | ABL1 (0.51) | ADORA1ADORA2ADHFRALDH1A1LMNA | |
| SCHEMBL7468146 | 0.81 | DHFR (0.48) | ADORA1ADORA2ADHFRIDO1ABL1 | |
| SCHEMBL5451849 | 0.77 | ADORA1 (0.64) | ADORA1ADORA2ADHFRALDH1A1KDM4E | |
| SCHEMBL7467727 | 0.73 | ADORA1 (0.42) | ADORA1ADORA2ADHFRALDH1A1KDM4E | |
| SCHEMBL7462501 | 0.72 | ADORA1 (0.60) | ADORA1ADORA2ALMNAMAPTPDE3B | |
| SCHEMBL7466847 | 0.71 | ADORA1 (0.50) | ADORA1ADORA2AALDH1A1LMNAMAPT | |
| SCHEMBL7458897 | 0.71 | ABL1 (0.55) | ADORA2AALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL5241771 | 0.71 | ADORA1 (0.49) | ADORA1ADORA2ADHFRALDH1A1KDM4E | |
| SCHEMBL19031368 | 0.70 | IDO1 (0.48) | LMNAMAPTIDO1ABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |