Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471062 | 0.88 | ABL1 (0.51) | ADORA1ADORA2ACYP3A4TSHRCYP1A2 | |
| SCHEMBL7462501 | 0.86 | ADORA1 (0.60) | ADORA1ADORA2ACYP3A4TSHRALOX15 | |
| SCHEMBL7535967 | 0.82 | MEN1 (0.48) | ADORA1ADORA2ACYP3A4TSHRCYP1A2 | |
| SCHEMBL6832429 | 0.81 | ADORA1 (0.61) | ADORA1ADORA2AKMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL28118705 | 0.80 | ADORA1 (0.74) | ADORA1ADORA2AKMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL7463419 | 0.78 | ADORA1 (0.59) | ADORA1ADORA2AABL1PDGFRBBCR | |
| SCHEMBL6831577 | 0.73 | MEN1 (0.59) | ADORA1ADORA2AMEN1MKNK1MKNK2 | |
| SCHEMBL7468146 | 0.73 | DHFR (0.48) | ADORA1ADORA2AABL1PDGFRBBCR | |
| SCHEMBL6832217 | 0.72 | ADORA1 (0.53) | ADORA1ADORA2AKMT2ACYP2A6HSP90AA1 | |
| SCHEMBL7467735 | 0.71 | ADORA1 (0.42) | ADORA1ADORA2ALMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |