Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 16/20 | 0.68 |
| ▸ | KCNQ1 | P51787 | 16/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464216 | 0.89 | KCNE1 (0.69) | KCNE1KCNQ1MEN1CYP1A2CYP3A4 | |
| SCHEMBL8476662 | 0.83 | KCNE1 (0.55) | KCNE1KCNQ1MEN1KMT2AKCNA5 | |
| SCHEMBL8479087 | 0.80 | KCNE1 (0.76) | KCNE1KCNQ1CYP3A4KCNH2KCNA5 | |
| SCHEMBL8479300 | 0.80 | KCNE1 (0.71) | KCNE1KCNQ1MEN1CYP1A2CYP3A4 | |
| SCHEMBL9398509 | 0.75 | KDM4E (0.68) | KCNE1KCNQ1MEN1CYP1A2CYP3A4 | |
| SCHEMBL9397745 | 0.71 | KCNE1 (0.59) | KCNE1KCNQ1CYP3A4KDM4E | |
| SCHEMBL9397763 | 0.71 | KCNE1 (0.59) | KCNE1KCNQ1CYP3A4KDM4E | |
| SCHEMBL9397756 | 0.71 | KCNE1 (0.59) | KCNE1KCNQ1CYP3A4KDM4E | |
| SCHEMBL8613564 | 0.71 | ABCC8 (0.68) | KCNE1KCNQ1MEN1CYP1A2CYP3A4 | |
| SCHEMBL9229335 | 0.71 | ABCC8 (0.68) | KCNE1KCNQ1MEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |