Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841070 | 0.84 | LOXL2 (0.41) | LOXL2HRH3CYP2A6TYMPIDH1 | |
| Hydrochloric Acid SCHEMBL7831351 | 0.81 | LOXL2 (0.41) | LOXL2HRH3CYP2A6TYMPIDH1 | |
| SCHEMBL15515881 | 0.80 | LTB4R (0.47) | KDM4EKMT2AALDH1A1TSHR | |
| SCHEMBL7466369 | 0.79 | TYMP (0.41) | LOXL2HRH3CYP2A6TYMPIDH1 | |
| Hydrochloric Acid SCHEMBL7841514 | 0.79 | LOXL2 (0.40) | LOXL2HRH3CYP2A6TYMPIDH1 | |
| SCHEMBL8110738 | 0.76 | LTB4R (0.42) | GRIN1GRIN2BCYP11B1CYP11B2KDM4E | |
| SCHEMBL8521752 | 0.74 | GRIN1 (0.39) | LOXL2HRH3CYP2A6TYMPGRIN1 | |
| Hydrochloric Acid SCHEMBL7975068 | 0.73 | LOXL2 (0.39) | LOXL2HRH3CYP2A6TYMPIDH1 | |
| SCHEMBL8305497 | 0.72 | GRIN1 (0.42) | LOXL2HRH3TYMPGRIN1GRIN2B | |
| SCHEMBL6949338 | 0.70 | HRH3 (0.41) | LOXL2HRH3CYP2A6TYMPSAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165013-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1165013-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000051547-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-09-08 | — | — | WO | disclosed |