Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.50 |
| ▸ | HPGD | P15428 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 12/20 | 0.49 |
| ▸ | GLA | P06280 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | CASP1 | P29466 | 3/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558676 | 0.87 | KDM4E (0.45) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL6558667 | 0.87 | KDM4E (0.45) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL6559505 | 0.83 | KDM4E (0.61) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL6559504 | 0.83 | KDM4E (0.61) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL6603109 | 0.82 | MAOB (0.60) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL6603113 | 0.82 | MAOB (0.60) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL6935038 | 0.81 | KDM4E (0.69) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL6558746 | 0.78 | MAPT (0.41) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL6558749 | 0.78 | MAPT (0.41) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL6559530 | 0.76 | KDM4E (0.49) | ALDH1A1KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |