Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | GLA | P06280 | 4/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | PPIB | P23284 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559505 | 1.00 | KDM4E (0.61) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL7830552 | 0.89 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL6593237 | 0.89 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL7467920 | 0.83 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL7467918 | 0.83 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL621021 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL621022 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL6559535 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL6559530 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL6603109 | 0.80 | MAOB (0.60) | KDM4EALDH1A1MAPTTDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |