Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 4/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTPRF | P10586 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL746843 | 0.86 | HPGD (0.51) | LMNAALDH1A1KDM4EHSD17B10ERN1 | |
| SCHEMBL19738077 | 0.83 | CYP3A4 (0.36) | LMNAALDH1A1KDM4EHSD17B10ERN1 | |
| SCHEMBL20562637 | 0.80 | PTPRF (0.46) | LMNAALDH1A1ERN1POLBPTPRF | |
| SCHEMBL10598205 | 0.78 | PTPRF (0.44) | LMNAALDH1A1ERN1CTNNB1WNT3A | |
| SCHEMBL12998493 | 0.77 | ALDH1A1 (0.49) | LMNAALDH1A1KDM4EHSD17B10ERN1 | |
| SCHEMBL31371848 | 0.76 | LMNA (0.42) | LMNAALDH1A1KDM4EHSD17B10ERN1 | |
| SCHEMBL27432418 | 0.75 | LMNA (0.44) | LMNAALDH1A1KDM4EHSD17B10ERN1 | |
| SCHEMBL16703478 | 0.75 | LMNA (0.44) | LMNAALDH1A1KDM4EHSD17B10ERN1 | |
| SCHEMBL30608694 | 0.74 | ERN1 (0.55) | ALDH1A1KDM4EERN1POLBTDP1 | |
| SCHEMBL6607327 | 0.74 | ALDH1A1 (0.54) | LMNAALDH1A1KDM4EHSD17B10ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242970-B2 | Lactam derivatives useful as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-01-26 | — | — | US | disclosed |
| EP-2638008-B1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-07-01 | — | — | EP | disclosed |
| EP-2638008-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2013-09-18 | — | — | EP | disclosed |
| US-20130237525-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-09-12 | — | — | US | disclosed |
| EP-2430004-B1 | NOVEL OXAZOLIDINONE DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-07-17 | — | — | EP | disclosed |
| US-8329706-B2 | Oxazolidinone derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-12-11 | — | — | US | disclosed |
| US-8329706-B2 | Oxazolidinone derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-12-11 | — | — | US | disclosed |
| WO-2012063207-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-05-18 | — | — | WO | disclosed |
| US-20120101111-A1 | NOVEL OXAZOLIDINONE DERIVIATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2012-04-26 | — | — | US | disclosed |
| US-20120101111-A1 | NOVEL OXAZOLIDINONE DERIVIATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2012-04-26 | — | — | US | disclosed |
| WO-2010131191-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010131191-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-18 | — | — | WO | disclosed |
| EP-2024401-A2 | HIGH TEMPERATURE POLYETHYLENE SOLUTION POLYMERIZATION PROCESS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007136496-A2 | HIGH TEMPERATURE POLYETHYLENE SOLUTION POLYMERIZATION PROCESS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| US-5708020-A | FOR TREATING SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-13 | — | — | US | disclosed |
| US-5604261-A | HAVING HYDROXYL/ALKOXYL GROUP ORTHO TO AMIDE GROUP ON PHENYL RING; HIGH MELATONIN RECEPTOR AFFINITY | ADIR ET COMPAGNIE (FR) | 1997-02-18 | — | — | US | disclosed |
| US-5554642-A | USE TO TREAT MAMMALS AFFLICTED WITH SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1996-09-10 | — | — | US | disclosed |
| EP-0591057-B1 | Arylalkyl(thio)amides with melatonine receptor selectivity and process for their preparation | ADIR (FR) | 1996-07-10 | — | — | EP | disclosed |
| US-5464872-A | Sleep disorders | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0591057-A1 | Arylalkyl(thio)amides with melatonine receptor selectivity and process for their preparation | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101111-A1 | NOVEL OXAZOLIDINONE DERIVIATIVES | HCRTR2, HCRTR1, NPY4R | LMNA 3789/4885ALDH1A1 715/4885KDM4E 1180/4885 |
| US-20130237525-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | LMNA 3751/4885ALDH1A1 2282/4885KDM4E 2065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.