Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.71 |
| ▸ | BCR | P11274 | 8/20 | 0.71 |
| ▸ | SRC | P12931 | 3/20 | 0.71 |
| ▸ | PRKCA | P17252 | 5/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.62 |
| ▸ | CDK4 | P11802 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | PRKACG | P22612 | 1/20 | 0.54 |
| ▸ | PRKACB | P22694 | 1/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27116472 | 0.86 | CDK2 (0.57) | ABL1BCRSRCPRKCAPIK3CG | |
| SCHEMBL7461678 | 0.86 | ABL1 (0.73) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL27115951 | 0.86 | PIK3CG (0.62) | ABL1BCRSRCPIK3CGPIK3CA | |
| SCHEMBL7467324 | 0.83 | ABL1 (0.76) | ABL1BCRSRCPRKCAPIK3CG | |
| SCHEMBL1789 | 0.83 | ABL1 (1.00) | ABL1BCRSRCPRKCAPIK3CG | |
| SCHEMBL4899574 | 0.83 | ABL1 (0.76) | ABL1BCRSRCPRKCACDK4 | |
| SCHEMBL4736185 | 0.83 | PIK3CG (0.80) | ABL1BCRPIK3CGPIK3CACDK4 | |
| SCHEMBL4901590 | 0.83 | ABL1 (0.67) | ABL1BCRSRCPRKCACDK4 | |
| SCHEMBL4732256 | 0.83 | PLK1 (0.59) | ABL1BCRSRCPRKCAPIK3CG | |
| SCHEMBL7467852 | 0.82 | PIK3CA (0.65) | ABL1BCRSRCPRKCAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |