Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.76 |
| ▸ | BCR | P11274 | 8/20 | 0.76 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.76 |
| ▸ | SRC | P12931 | 4/20 | 0.71 |
| ▸ | PRKCA | P17252 | 4/20 | 0.64 |
| ▸ | CDK2 | P24941 | 2/20 | 0.63 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.63 |
| ▸ | SYK | P43405 | 1/20 | 0.63 |
| ▸ | CDK1 | P06493 | 2/20 | 0.61 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2322043 | 0.88 | PIK3CG (0.70) | ABL1BCRPIK3CGPIK3CASRC | |
| SCHEMBL2331086 | 0.88 | PIK3CG (0.70) | ABL1BCRPIK3CGPIK3CASRC | |
| SCHEMBL7471347 | 0.87 | SRC (0.64) | ABL1BCRPIK3CGPIK3CASRC | |
| Hydrochloric Acid SCHEMBL16496538 | 0.86 | PIK3CG (0.69) | ABL1BCRPIK3CGPIK3CASRC | |
| SCHEMBL27115444 | 0.86 | PIK3CA (0.69) | ABL1BCRPIK3CGPIK3CASRC | |
| SCHEMBL7476769 | 0.86 | ABL1 (1.00) | ABL1BCRPIK3CGPIK3CASRC | |
| SCHEMBL7813342 | 0.85 | PIK3CA (0.67) | ABL1BCRPIK3CGPIK3CASRC | |
| SCHEMBL7470733 | 0.84 | PIK3CA (0.66) | ABL1BCRPIK3CGPIK3CASRC | |
| SCHEMBL27115445 | 0.84 | PIK3CG (0.66) | ABL1BCRPIK3CGPIK3CASRC | |
| SCHEMBL1789 | 0.83 | ABL1 (1.00) | ABL1BCRPIK3CGPIK3CASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | claimed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | claimed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |