Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 12/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10750155 | 0.88 | TBXAS1 (0.97) | TBXAS1ALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL3005716 | 0.84 | TBXAS1 (1.00) | TBXAS1ALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL1928520 | 0.80 | TBXAS1 (0.68) | TBXAS1ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL9451380 | 0.80 | TBXAS1 (0.68) | TBXAS1ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7460532 | 0.78 | TBXAS1 (0.59) | TBXAS1ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL6302832 | 0.78 | TBXAS1 (0.87) | TBXAS1MEN1LMNAKMT2A | |
| SCHEMBL12382 | 0.78 | KMT2A (0.87) | TBXAS1ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL3581172 | 0.78 | ALDH1A1 (0.85) | TBXAS1ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL25344191 | 0.77 | TBXAS1 (0.64) | TBXAS1ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL8685423 | 0.77 | TBXAS1 (0.80) | TBXAS1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |