Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322574 | 0.91 | MAPK14 (0.61) | MAPK14TSHRPARP1SIGMAR1KDM4E | |
| Hydrochloric Acid SCHEMBL7468024 | 0.90 | MAPK14 (0.60) | MAPK14TSHRPARP1SIGMAR1KDM4E | |
| SCHEMBL7476872 | 0.85 | MAPK14 (0.45) | MAPK14 | |
| SCHEMBL7470777 | 0.83 | MAPK1 (0.40) | MAPK14PARP1 | |
| SCHEMBL7474456 | 0.82 | MAPK14 (0.52) | MAPK14 | |
| SCHEMBL1383396 | 0.82 | MAPK14 (0.52) | MAPK14 | |
| Hydrochloric Acid SCHEMBL7473782 | 0.81 | MAPK14 (0.51) | MAPK14 | |
| SCHEMBL7474749 | 0.81 | CYP2D6 (0.49) | CYP2D6 | |
| SCHEMBL7475922 | 0.81 | MAPK14 (0.44) | MAPK14DRD2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL7812428 | 0.81 | MAPK14 (0.55) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | disclosed |