Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.41 |
| ▸ | NPC1 | O15118 | 11/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.41 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6709122 | 0.94 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL6707866 | 0.91 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL6707187 | 0.81 | NPC1 (0.61) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL6707106 | 0.79 | HPGD (0.49) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL6709542 | 0.78 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL6710604 | 0.77 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL6709332 | 0.76 | RAB9A (0.41) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL6709086 | 0.74 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL6707133 | 0.72 | ALDH1A1 (0.55) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL6707854 | 0.70 | ALDH1A1 (0.44) | RAB9ANPC1SMN1; SMN2TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012150-A4 | HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS | SUGEN INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1012150-A1 | HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS | Sugen, Inc. (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998052944-A1 | HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS | SUGEN, INC. (US) | 1998-11-26 | — | — | WO | disclosed |